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A Randomized, Double-Blind, Placebo Controlled Study to Evaluate Safety and Efficacy of DUR-928 in Subjects Infected With SARS-CoV-2 With Acute Lung, Liver or Kidney Injury

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Trial Profile

A Randomized, Double-Blind, Placebo Controlled Study to Evaluate Safety and Efficacy of DUR-928 in Subjects Infected With SARS-CoV-2 With Acute Lung, Liver or Kidney Injury

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 10 Aug 2022

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At a glance

  • Drugs Larsucosterol (Primary)
  • Indications COVID-19 pneumonia; COVID-19 respiratory infection; Kidney disorders; Liver injury
  • Focus Proof of concept; Therapeutic Use
  • Sponsors DURECT Corporation

Most Recent Events

  • 18 Mar 2021 Status changed from recruiting to discontinued due to low enrollment.
  • 02 Nov 2020 According to a DURECT Corporation media release, Patients will receive a dose of 150 mg of DUR-928 or placebo by intravenous infusion on day 1 and day 4 in combination with standard of care therapy, which will be determined by the principal investigator at each clinical trial site.Any drug product(s) determined by the FDA to be safe and effective for the treatment of COVID-19 while the trial is ongoing may be offered, at each PI's discretion, to any remaining and future patients in this trial
  • 29 Sep 2020 Planned End Date changed from 1 Jan 2021 to 1 Oct 2021.

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