Trial Profile

Open-label, Single-arm Trial to Evaluate Antitumor Activity, Safety, and Pharmacokinetics of Tusamitamab Ravtansine (SAR408701) Used in Combination With Ramucirumab or Ramucirumab and Pembrolizumab in Metastatic, Non-squamous, Non Small-cell Lung Cancer (NSQ NSCLC) Patients With CEACAM5-positive Tumors, Previously Treated With Platinum-based Chemotherapy and an Immune Checkpoint Inhibitor

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 08 Jun 2025

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At a glance

Drugs Pembrolizumab (Primary) ; Ramucirumab (Primary) ; Tusamitamab ravtansine (Primary)
Indications Non-small cell lung cancer
Focus Adverse reactions; Therapeutic Use
Acronyms CARMEN-LC04
Sponsors Sanofi

30 Oct 2024 According to ClinicalTrials.gov , this trial is terminated due Sponsor decision, the decision is not related to any safety concern.
30 Oct 2024 Status changed from active, no longer recruiting to discontinued.
29 Apr 2024 Planned End Date changed from 29 Mar 2024 to 30 Sep 2024.

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