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A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab Versus Temozolomide in Patients With Newly Diagnosed MGMT (Tumor O-6-Methylguanine DNA Methyltransferase) Unmethylated Glioblastoma

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Trial Profile

A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab Versus Temozolomide in Patients With Newly Diagnosed MGMT (Tumor O-6-Methylguanine DNA Methyltransferase) Unmethylated Glioblastoma

Status: Active, no longer recruiting
Phase of Trial: Phase II/III

Latest Information Update: 28 Apr 2025

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At a glance

  • Drugs Ipilimumab (Primary) ; Nivolumab (Primary) ; Temozolomide
  • Indications Glioblastoma; Gliosarcoma
  • Focus Therapeutic Use

Most Recent Events

  • 22 Apr 2025 Planned End Date changed from 11 Mar 2025 to 11 Mar 2026.
  • 12 Mar 2024 Planned End Date changed from 23 Aug 2024 to 11 Mar 2025.
  • 30 Mar 2023 Status changed from suspended to active, no longer recruiting.

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