Trial Profile

A Two Cohort, Open-Label, Fixed Sequence Study to Investigate the Effect of CYP3A4 Inhibition on the Single Dose Pharmacokinetics of ASTX660 and the Effect of a Single Dose of ASTX660 on the Pharmacokinetics of the CYP3A4 Substrate Midazolam

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 04 Nov 2021

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At a glance

Drugs Tolinapant (Primary) ; Itraconazole; Midazolam
Indications Acute myeloid leukaemia; Lymphoma; Solid tumours; T-cell lymphoma
Focus Pharmacokinetics
Sponsors Astex Pharmaceuticals

14 Sep 2020 Status changed from recruiting to completed.
07 Jul 2020 Planned End Date changed from 11 Jul 2020 to 8 Aug 2020.
07 Jul 2020 Planned primary completion date changed from 3 Jul 2020 to 2 Aug 2020.

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