Trial Profile

A Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of TAK-186 (Also Known as MVC-101), An EGFR x CD3 COnditional Bispecific Redirected Activation (COBRA) Protein in Patients With Unresectable Locally Advanced or Metastatic Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 20 Mar 2025

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At a glance

Drugs TAK 186 (Primary)
Indications Colorectal cancer; Head and neck cancer; Non-small cell lung cancer; Solid tumours; Squamous cell cancer
Focus Adverse reactions; First in man
Sponsors Maverick Therapeutics; Takeda

14 Mar 2025 Status changed from recruiting to active, no longer recruiting.
14 Mar 2024 Planned number of patients changed from 228 to 258.
24 Oct 2023 Trial design presented at the 48th European Society for Medical Oncology Congress

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