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A Phase III, Randomized, Open-Label, Active-Controlled, Multicenter Study Evaluating The Safety, Pharmacokinetics, Pharmacodynamic And Efficacy of Crovalimab Versus Eculizumab In Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

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Trial Profile

A Phase III, Randomized, Open-Label, Active-Controlled, Multicenter Study Evaluating The Safety, Pharmacokinetics, Pharmacodynamic And Efficacy of Crovalimab Versus Eculizumab In Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 04 Aug 2026

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At a glance

  • Drugs Crovalimab (Primary) ; Crovalimab (Primary) ; Eculizumab
  • Indications Paroxysmal nocturnal haemoglobinuria
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms COMMODORE 1
  • Sponsors Roche

Most Recent Events

  • 28 Jul 2026 Planned End Date changed from 30 Sep 2027 to 18 Apr 2027.
  • 28 Jul 2026 Planned primary completion date changed from 30 Sep 2027 to 18 Apr 2027.
  • 02 Feb 2026 According to CTIS record, this study has been Completed in Spain, Czech Republic, Belgium, Estonia, Netherlands, Portugal, Germany, Poland and Italy.

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