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An Open-label, Phase 1/2 Trial of Gene Therapy 4D-125 in Males With X-linked Retinitis Pigmentosa (XLRP) Caused by Mutations in the RPGR Gene

Trial Profile

An Open-label, Phase 1/2 Trial of Gene Therapy 4D-125 in Males With X-linked Retinitis Pigmentosa (XLRP) Caused by Mutations in the RPGR Gene

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 23 Mar 2025

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At a glance

  • Drugs 4D 125 (Primary)
  • Indications Retinitis pigmentosa
  • Focus Adverse reactions; First in man; Proof of concept
  • Sponsors 4D Molecular Therapeutics

Most Recent Events

  • 13 Nov 2024 According to a 4D Molecular Therapeutics media release, Program updates expected in early January 2025.
  • 08 Aug 2024 According to a 4D Molecular Therapeutics media release,Program updates expected in Q4 2024.
  • 09 Jan 2023 According to a 4D Molecular Therapeutics media release, enrollment in this phase 1/2 study has been completed in the fourth quarter of 2022. The company will continue to follow these patients for 24 months and anticipate clinical data updates in 2024.

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