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Phase III Study of Isatuximab-Carfilzomib-Lenalidomide-Dexamethasone (Isa-KRd) Versus Carfilzomib-Lenalidomide-Dexamethasone (KRd) in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL)

Trial Profile

Phase III Study of Isatuximab-Carfilzomib-Lenalidomide-Dexamethasone (Isa-KRd) Versus Carfilzomib-Lenalidomide-Dexamethasone (KRd) in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 05 Jun 2025

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At a glance

  • Drugs Carfilzomib (Primary) ; Dexamethasone (Primary) ; Dexamethasone (Primary) ; Isatuximab (Primary) ; Lenalidomide (Primary) ; Cyclophosphamide; Melphalan
  • Indications Multiple myeloma
  • Focus Therapeutic Use
  • Acronyms IsKia

Most Recent Events

  • 30 May 2025 According to an Adaptive Biotechnologies media release, company will present result data from this study utilizing clonoSEQ MRD assessment as a critical indicator of quadruplet regimen efficacy in multiple myeloma at the American Society of Clinical Oncology (ASCO) Annual Meeting taking place May 30-June 3 in Chicago.
  • 12 Dec 2023 Results(n=302), presented at the 65th American Society of Hematology Annual Meeting and Exposition
  • 11 Dec 2023 Primary endpoint (Rate of MRD negativity after ASCT consolidation treatment by NGS) has been met, according to a Sanofi media release.

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