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A Phase 1, Double-blind, Randomized, Placebo-controlled, First-in-human Study of Subcutaneously Administered ALG-010133 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single Ascending Doses (Part 1) and Multiple Ascending Doses in Healthy Volunteers (Part 2), and Multiple Doses in Subjects With Chronic Hepatitis B (Part 3)

Trial Profile

A Phase 1, Double-blind, Randomized, Placebo-controlled, First-in-human Study of Subcutaneously Administered ALG-010133 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single Ascending Doses (Part 1) and Multiple Ascending Doses in Healthy Volunteers (Part 2), and Multiple Doses in Subjects With Chronic Hepatitis B (Part 3)

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 20 Aug 2022

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At a glance

  • Drugs ALG 010133 (Primary)
  • Indications Hepatitis B
  • Focus Adverse reactions; First in man; Proof of concept
  • Sponsors Aligos Therapeutics

Most Recent Events

  • 26 Jun 2022 Results presented at The International Liver Congress 2022
  • 14 Mar 2022 Status changed from active, no longer recruiting to discontinued due to lack of antiviral activity at the projected efficacious dose.
  • 14 Feb 2022 Planned End Date changed from 1 Aug 2022 to 1 Apr 2022.

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