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An Adaptive Phase I/II Randomized Placebo-controlled Trial to Determine Safety, Immunogenicity and Efficacy of Non-replicating ChAdOx1 SARS-CoV-2 Vaccine in South African Adults Living Without HIV; and Safety and Immunogenicity in Adults Living With HIV

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Trial Profile

An Adaptive Phase I/II Randomized Placebo-controlled Trial to Determine Safety, Immunogenicity and Efficacy of Non-replicating ChAdOx1 SARS-CoV-2 Vaccine in South African Adults Living Without HIV; and Safety and Immunogenicity in Adults Living With HIV

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 03 Jan 2024

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At a glance

  • Drugs AZD 1222 (Primary)
  • Indications COVID 2019 infections
  • Focus Adverse reactions; Pharmacodynamics; Therapeutic Use
  • Acronyms COV005

    • Most Recent Events

    • 06 Nov 2023 According to Barinthus Biotherapeutics media release, Vaccitech has changed its name to Barinthus Biotherapeutics .
    • 01 Jan 2023 Results (n=174) assessing the SARS-CoV-2 specific T-cell responses 14 days after single-dose ChAdOx1 nCoV-19 (AZD1222) vaccination in black Africans with and without HIV in South Africa, as well as determine the effect of AZD1222 vaccination on cell-mediated immune responses in people with HIV (PWH) with prior SARS-CoV-2 infection, published in the AIDS.
    • 16 Mar 2021 Results published in the New England Journal of Medicine

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