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A Phase Ia/Ib Dose-Escalation and Dose-Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-6036 as a Single Agent and in Combination With Other Anti-cancer Therapies in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

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Trial Profile

A Phase Ia/Ib Dose-Escalation and Dose-Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-6036 as a Single Agent and in Combination With Other Anti-cancer Therapies in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 11 Jun 2025

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At a glance

  • Drugs Atezolizumab (Primary) ; Bevacizumab (Primary) ; Cetuximab (Primary) ; Divarasib (Primary) ; Erlotinib (Primary) ; Inavolisib (Primary) ; Migoprotafib (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Anal cancer; Appendiceal cancer; Cholangiocarcinoma; Colorectal cancer; Duodenal cancer; Endometrial cancer; Gastric cancer; Lung cancer; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions
  • Sponsors Genentech

Most Recent Events

  • 30 Apr 2025 Results (As of April 1, 2024, n=74 ) assessing safety and activity of combination divarasib and migoprotafib presented at the 116th Annual Meeting of the American Association for Cancer Research
  • 14 Feb 2025 Planned End Date changed from 31 Mar 2026 to 28 Feb 2026.
  • 14 Feb 2025 Planned primary completion date changed from 31 Mar 2025 to 28 Feb 2026.

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