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A Phase 1/2, Open-label, Multicenter Study to Investigate the Safety, Pharmacokinetics, and Efficacy of Fadraciclib (CYC065), an Oral CDK 2/9 Inhibitor, in Subjects With Advanced Solid Tumors and Lymphoma

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Trial Profile

A Phase 1/2, Open-label, Multicenter Study to Investigate the Safety, Pharmacokinetics, and Efficacy of Fadraciclib (CYC065), an Oral CDK 2/9 Inhibitor, in Subjects With Advanced Solid Tumors and Lymphoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 13 Dec 2024

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At a glance

  • Drugs Fadraciclib (Primary)
  • Indications Advanced breast cancer; B-cell lymphoma; Biliary cancer; Breast cancer; Carcinoma; Cervical cancer; Cholangiocarcinoma; Colorectal cancer; Cutaneous T-cell lymphoma; Endometrial cancer; HER2 negative breast cancer; Leiomyosarcoma; Liver cancer; Lymphoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Peripheral T-cell lymphoma; Solid tumours; Squamous cell cancer; T-cell lymphoma; Testicular cancer; Uterine cancer
  • Focus Adverse reactions; Proof of concept; Registrational; Therapeutic Use
  • Sponsors Cyclacel Pharmaceuticals

    • Most Recent Events

    • 25 Oct 2024 Results(n=50) evaluating safety and efficacy of Fadraciclib presented at the 36th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics.
    • 23 Oct 2024 According to a Cyclacel Pharmaceuticals media release, data from this study were presented at the 2024 EORTC-NCI-AACR 36th Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain (October 23-25, 2024).
    • 23 Oct 2024 Interim results were presented in a Cyclacel Pharmaceuticals Media Release.

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