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A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease Has Remained Stable or Responded to First-Line Platinum Based Chemotherapy With Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL-1L)

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Trial Profile

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease Has Remained Stable or Responded to First-Line Platinum Based Chemotherapy With Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL-1L)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 17 Jul 2024

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At a glance

  • Drugs Niraparib (Primary) ; Pembrolizumab (Primary)
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms ZEAL-1L
  • Sponsors GlaxoSmithKline; GlaxoSmithKline Research & Development; GSK

    • Most Recent Events

    • 19 Jan 2023 Status changed from recruiting to active, no longer recruiting.
    • 26 Aug 2022 Planned End Date changed from 28 Oct 2024 to 19 Feb 2025.
    • 26 Aug 2022 Planned primary completion date changed from 28 Aug 2024 to 20 Dec 2024.

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