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A Phase 1/2 Dose Escalation and Cohort Expansion Study of LP-184 in Patients with Advanced or Metastatic Solid Tumors

Trial Profile

A Phase 1/2 Dose Escalation and Cohort Expansion Study of LP-184 in Patients with Advanced or Metastatic Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 Dec 2025

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At a glance

  • Drugs Irofulven (Primary) ; Spironolactone
  • Indications Adenocarcinoma; Bladder cancer; Brain cancer; Brain metastases; Gastrointestinal stromal tumours; Glioblastoma; Glioma; Lung cancer; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Squamous cell cancer; Thymic epithelial tumour; Triple negative breast cancer
  • Focus Adverse reactions; First in man
  • Sponsors Lantern Pharma

Most Recent Events

  • 03 Dec 2025 According to Lantern Pharma media release, Phase 1a dose-escalation study has been completed.
  • 03 Dec 2025 Results published in the Lantern Pharma Media Release
  • 13 Nov 2025 According to Lantern Pharma media release ,Comprehensive results from the LP-184 Phase 1a trial are being prepared for submission to peer-reviewed journals and presentation at major oncology conferences. To provide additional insights and expert analysis of the clinical data the company will host a webinar (KOL)on 20 th November 2025.

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