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A Phase 1/2 Dose Escalation and Cohort Expansion Study of LP-184 in Patients with Advanced or Metastatic Solid Tumors

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Trial Profile

A Phase 1/2 Dose Escalation and Cohort Expansion Study of LP-184 in Patients with Advanced or Metastatic Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 03 Nov 2025

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At a glance

  • Drugs Irofulven (Primary) ; Spironolactone
  • Indications Adenocarcinoma; Bladder cancer; Brain cancer; Brain metastases; Glioblastoma; Glioma; Lung cancer; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Triple negative breast cancer
  • Focus Adverse reactions; First in man
  • Sponsors Lantern Pharma

Most Recent Events

  • 16 Sep 2025 According to Lantern Pharma media release, Primary endpoint has been met. (To determine the RP2D of LP-184 based on all available safety (graded by CTCAE v5.0), PK, PD and efficacy data)
  • 16 Sep 2025 According to Lantern Pharma media release, Primary endpoint has been met. (To determine the MTD of LP-184 based on all available safety (graded by CTCAE v5.0) and PK data.)
  • 16 Sep 2025 According to Lantern Pharma media release, Primary endpoint has been met. (To evaluate the safety and tolerability of LP-184 assessed by the incidence and severity of all adverse events graded by CTCAE v5.0)

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