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A Phase 2, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd, DS-8201a) for the Treatment of Selected HER2 Expressing Tumors (DESTINY-PanTumor02)

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A Phase 2, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd, DS-8201a) for the Treatment of Selected HER2 Expressing Tumors (DESTINY-PanTumor02)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 30 Sep 2024

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At a glance

  • Drugs Trastuzumab-deruxtecan (Primary)
  • Indications Adenoid cystic carcinoma; Biliary cancer; Bladder cancer; Carcinoma; Cervical cancer; Endometrial cancer; Gallbladder cancer; Ovarian cancer; Pancreatic cancer; Pelvic cancer; Renal cancer; Salivary gland cancer; Solid tumours; Squamous cell cancer; Ureteral neoplasms; Urethral cancer; Urogenital cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms DESTINY-PanTumor02; DPT02
  • Sponsors AstraZeneca; AstraZeneca AB

    • Most Recent Events

    • 04 Jun 2024 Results (At data cutoff (June 2023), n=24) assessing safety and efficacy of Trastuzumab deruxtecan in patients (pts) with HER2-expressing head and neck tumors presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 04 Jun 2024 Results (n=41; At data cutoff June 2023) assessing the efficacy and safety of subgroup analyses in the bladder cohort (urothelial carcinoma including transitional cell carcinoma of the renal pelvis, ureter, urinary bladder, or urethra), and characterize patients with an objective response, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 04 Jun 2024 Results (At data cutoff (June 2023), n=41) assessing efficacy of Trastuzumab deruxtecan in patients (pts) with HER2-expressing biliary tract cancer and pancreatic cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology

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