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An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined With Ruxolitinib in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post ET-MF) Who Have a Suboptimal Response to Ruxolitinib

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Trial Profile

An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined With Ruxolitinib in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post ET-MF) Who Have a Suboptimal Response to Ruxolitinib

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 06 Jun 2024

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At a glance

  • Drugs Navtemadlin (Primary) ; Ruxolitinib (Primary)
  • Indications Myelofibrosis
  • Focus Adverse reactions; Pharmacodynamics
  • Sponsors Kartos Therapeutics
  • Most Recent Events

    • 03 Jun 2024 This trial has been completed in Bulgaria according to European Clinical Trials Database record.
    • 17 May 2024 This trial has been completed in Germany.
    • 15 Jun 2023 Results (n=32) assessing safety, efficacy, and tolerability of nvtm added to rux in MF pts with suboptimal response to rux presented at the 28th Congress of the European Haematology Association
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