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A Multicenter Platform Trial of Putative Therapeutics for the Treatment of COVID-19 in Hospitalized Adults

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Trial Profile

A Multicenter Platform Trial of Putative Therapeutics for the Treatment of COVID-19 in Hospitalized Adults

Status: Completed
Phase of Trial: Phase II/III

Latest Information Update: 07 Jun 2023

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At a glance

  • Drugs Lenzilumab (Primary) ; Remdesivir (Primary)
  • Indications Respiratory insufficiency; SARS-CoV-2 acute respiratory disease
  • Focus Proof of concept; Registrational; Therapeutic Use
  • Acronyms ACTIV-5; ACTIV-5/BET-B; ACTIV-5BET; BET

    • Most Recent Events

    • 12 Jul 2022 Primary endpoint (Occurrence of mechanical ventilation or death at any point through Day 29 in subjects with ordinal scores of 5 or 6 at baseline) has not been met, according to a Humanigen media release.
    • 12 Jul 2022 Preliminary topline results published in the Humanigen Media Release.
    • 30 Jun 2022 According to a Humanigen media release, the company has received a notice from NIH/NIAID that they have cleaned and locked the blinded data in the study. The company expects to receive topline results from NIH/NIAID in July.

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