Trial Profile

An Open-Label, Phase 1/1b Study of ORIC-944 As a Single Agent or in Combination with an Androgen Receptor Pathway Inhibitor in Patients with Metastatic Prostate Cancer

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 13 Feb 2026

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At a glance

Drugs Apalutamide (Primary) ; Darolutamide (Primary) ; Rinzimetostat (Primary)
Indications Neuroendocrine carcinoma; Prostate cancer
Focus Adverse reactions; First in man; Pharmacokinetics
Sponsors ORIC Pharmaceuticals

12 Jan 2026 According to an ORIC Pharmaceuticals media release, company has completed Phase 1b dose exploration in prostate cancer and selected provisional recommended Phase 2 doses (RP2Ds) of rinzimetostat to be tested in combination with the approved doses of darolutamide and apalutamide in dose optimization.
14 Nov 2025 According to an ORIC Pharmaceuticals media release, company plans to announce preliminary dose optimization data in 1Q 2026.
14 Nov 2025 Results presented in the ORIC Pharmaceuticals media release

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