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An Open-Label, Phase 1/1b Study of ORIC-944 As a Single Agent or in Combination with an Androgen Receptor Pathway Inhibitor in Patients with Metastatic Prostate Cancer

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Trial Profile

An Open-Label, Phase 1/1b Study of ORIC-944 As a Single Agent or in Combination with an Androgen Receptor Pathway Inhibitor in Patients with Metastatic Prostate Cancer

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 30 May 2025

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At a glance

  • Drugs Apalutamide (Primary) ; Darolutamide (Primary) ; ORIC-944 (Primary)
  • Indications Neuroendocrine carcinoma; Prostate cancer
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors ORIC Pharmaceuticals

Most Recent Events

  • 27 May 2025 According to an ORIC Pharmaceuticals media release, Following completion of the Phase 1b dose exploration portion of the trial expected in mid-2025, the company plans to evaluate two candidate RP2Ds for each combination in the dose optimization portion of the trial in 2H 2025.
  • 27 May 2025 Results presented in the ORIC Pharmaceuticals Media Release
  • 20 Mar 2025 Planned primary completion date changed from 1 Dec 2024 to 1 Dec 2025.

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