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A Randomized, Double-blind, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Single and 14-day Repeated Oral Doses of SAR443820 in Healthy Adult Participants

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Trial Profile

A Randomized, Double-blind, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Single and 14-day Repeated Oral Doses of SAR443820 in Healthy Adult Participants

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 16 Jun 2023

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At a glance

  • Drugs DNL 788 (Primary)
  • Indications Alzheimer's disease; Amyotrophic lateral sclerosis; Multiple sclerosis
  • Focus Adverse reactions; First in man
  • Sponsors Sanofi

    • Most Recent Events

    • 27 Apr 2023 Results assessing safety, tolerability, pharmacokinetics, and pharmacodynamics of SAR443820 in first-in-human, Phase 1, randomized, double-blind, placebo-controlled, single-ascending dose (SAD; Part-1a) and multiple-ascending dose (MAD; Part-2) studies in healthy participants, presented at the 75th Annual Meeting of the American Academy of Neurology 2023.
    • 21 Mar 2023 Status changed from recruiting to completed.
    • 12 Jan 2021 Status changed from planning to recruiting, according to a Denali Therapeutics Inc media release.

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