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TOPAZ: Single Arm, Open Label Phase 1b/2 Study of Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain Metastases

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Trial Profile

TOPAZ: Single Arm, Open Label Phase 1b/2 Study of Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain Metastases

Status: Withdrawn prior to enrolment
Phase of Trial: Phase I/II

Latest Information Update: 04 Jul 2022

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At a glance

  • Drugs Pembrolizumab (Primary) ; Trastuzumab (Primary) ; Tucatinib (Primary)
  • Indications Advanced breast cancer; Brain metastases; HER2 positive breast cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms Topaz

    • Most Recent Events

    • 28 Jun 2022 Planned initiation date changed from 1 Jan 2021 to 1 Jun 2022.
    • 28 Jun 2022 Status changed from suspended to withdrawn prior to enrolment.
    • 14 Jan 2022 Planned End Date changed from 1 Oct 2023 to 1 Jun 2024.

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