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A Phase Ib/IIa, Dose-escalation Study to Evaluate the Safety, Tolerability, and Preliminary Effectiveness of Intratumoural Tigilanol Tiglate in Combination With Intravenous Pembrolizumab in Adults With Stage IIIb to IV M1c-melanoma

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Trial Profile

A Phase Ib/IIa, Dose-escalation Study to Evaluate the Safety, Tolerability, and Preliminary Effectiveness of Intratumoural Tigilanol Tiglate in Combination With Intravenous Pembrolizumab in Adults With Stage IIIb to IV M1c-melanoma

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 20 Apr 2023

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At a glance

  • Drugs Pembrolizumab (Primary) ; Tigilanol tiglate (Primary)
  • Indications Malignant melanoma
  • Focus Adverse reactions
  • Sponsors QBiotics

    • Most Recent Events

    • 13 Apr 2023 Status changed from recruiting to discontinued.
    • 14 Feb 2023 According to a QBiotics media release, following completion of a review of its human clinical oncology programme, the Company has resolved to close its melanoma clinical trials; the tigilanol tiglate monotherapy study QB46C-H04, and the tigilanol tiglate pembrolizumab combination study QB46C-H06 will be discontinued.
    • 14 Oct 2022 Planned primary completion date changed from 1 Jul 2022 to 1 Jul 2023.

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