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A Phase 1b Study Evaluating the Safety, Tolerability and Preliminary Anti-tumor Activity of NT-I7 (Efineptakin Alfa) a Long-acting Human IL-7, Post-Kymriah® (Tisagenlecleucel), Post-Yescarta® (Axicabtagene Ciloleucel), or Post-Breyanzi® (Lisocabtagene Maraleucel) in Subjects With Relapsed/Refractory Large B-cell Lymphoma

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Trial Profile

A Phase 1b Study Evaluating the Safety, Tolerability and Preliminary Anti-tumor Activity of NT-I7 (Efineptakin Alfa) a Long-acting Human IL-7, Post-Kymriah® (Tisagenlecleucel), Post-Yescarta® (Axicabtagene Ciloleucel), or Post-Breyanzi® (Lisocabtagene Maraleucel) in Subjects With Relapsed/Refractory Large B-cell Lymphoma

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 26 Feb 2024

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At a glance

  • Drugs Efineptakin alfa (Primary) ; Axicabtagene ciloleucel; Lisocabtagene-maraleucel; Tisagenlecleucel
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma
  • Focus Adverse reactions
  • Sponsors NeoImmuneTech

    • Most Recent Events

    • 07 Apr 2023 Primary end-points have been updated to remove efficacy end-points, thus safety or "AR" remains the only trial focus.
    • 13 Dec 2022 Results assessing NT-I7 administration after tisagenlecleucel SOC for pts with r/r LBCL may increase expansion and persistence of CAR-T, increasing tumor response rate and improving clinical outcomes without safety concerns presented at the 64th American Society of Hematology Annual Meeting and Exposition
    • 04 Nov 2022 Results published in the Media Release

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