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A Phase 1/2 Open-label Study to Investigate the Safety, Efficacy, and Pharmacokinetics of Administration of Subcutaneous Blinatumomab for the Treatment of Adults and Adolescents with Relapsed or Refractory B cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL) and Minimal Residual Disease Positive (MRD+) B-ALL - 20180257

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Trial Profile

A Phase 1/2 Open-label Study to Investigate the Safety, Efficacy, and Pharmacokinetics of Administration of Subcutaneous Blinatumomab for the Treatment of Adults and Adolescents with Relapsed or Refractory B cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL) and Minimal Residual Disease Positive (MRD+) B-ALL - 20180257

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 19 Sep 2026

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At a glance

  • Drugs Blinatumomab (Primary)
  • Indications Precursor B-cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
  • Sponsors Amgen

Most Recent Events

  • 28 May 2026 Status changed from recruiting to active, no longer recruiting.
  • 15 May 2026 According to Clinical Trials Information System this study is Temporarily halted in Spain, Netherlands, Germany, France, Italy, Belgium and Romania
  • 17 Dec 2025 Planned primary completion date changed from 27 Jul 2027 to 24 Nov 2027.

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