Trial Profile

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 07 Sep 2026

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At a glance

Drugs Amezalpat (Primary) ; Atezolizumab (Primary) ; Bevacizumab (Primary) ; Imdatifan (Primary) ; IO-108 (Primary) ; Muzastotug (Primary) ; Tiragolumab (Primary) ; Tobemstomig (Primary) ; Tocilizumab (Primary)
Indications Liver cancer
Focus Adverse reactions; Therapeutic Use
Acronyms Morpheus-Liver
Sponsors Roche

03 Sep 2026 Status changed from recruiting to active, no longer recruiting.
23 Apr 2026 Planned End Date changed from 31 Dec 2027 to 30 Sep 2027.
23 Apr 2026 Planned primary completion date changed from 31 Dec 2027 to 30 Jul 2027.

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