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A Phase 1b/2, Open-Label, Safety and Efficacy Study of Epcoritamab (GEN3013; DuoBody-CD3xCD20) in Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

Trial Profile

A Phase 1b/2, Open-Label, Safety and Efficacy Study of Epcoritamab (GEN3013; DuoBody-CD3xCD20) in Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 24 Apr 2026

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At a glance

  • Drugs Epcoritamab (Primary) ; Cyclophosphamide; Doxorubicin; Lenalidomide; Pirtobrutinib; Prednisone; Rituximab; Venetoclax; Vincristine; Vinorelbine
  • Indications Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Richter's syndrome
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
  • Acronyms EPCORE CLL-1
  • Sponsors Genmab

Most Recent Events

  • 04 Mar 2026 Planned End Date changed from 1 Apr 2028 to 1 Feb 2028.
  • 04 Mar 2026 Planned primary completion date changed from 1 Feb 2028 to 1 Dec 2027.
  • 13 Feb 2026 Status changed from recruiting to active, no longer recruiting.

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