Trial Profile

A Phase 1b/2, Open-Label, Safety and Efficacy Study of Epcoritamab (GEN3013; DuoBody-CD3xCD20) in Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 09 Jun 2025

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At a glance

Drugs Epcoritamab (Primary) ; Cyclophosphamide; Doxorubicin; Lenalidomide; Pirtobrutinib; Prednisone; Rituximab; Venetoclax; Vincristine
Indications Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Richter's syndrome
Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
Acronyms EPCORE CLL-1
Sponsors Genmab

Most Recent Events

17 Apr 2025 Planned number of patients changed from 304 to 424.
07 Mar 2025 Planned number of patients changed from 184 to 304.
07 Mar 2025 Protocol has been amended, arms changed from 5 to 7, two new arms (Epcoritamab + Pirtobrutinib in R/R CLL/SLL and Fixed Duration Epcoritamab in R/R CLL/SLL) have been added.

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