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A Phase 1, Multicenter, Open-Label Study of CB-010, a CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy in Patients With Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

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Trial Profile

A Phase 1, Multicenter, Open-Label Study of CB-010, a CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy in Patients With Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 23 Nov 2024

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At a glance

  • Drugs CB-010 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms ANTLER
  • Sponsors Caribou Biosciences

    • Most Recent Events

    • 04 Jun 2024 Results (n=16) assessing safety, tolerability, and antitumor activity of CB-010 in patients (pts) with r/r B-NHL and determine RP2D, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 06 Jul 2023 According to a Caribou Biosciences media release,company expects to provide updates from this study over the next six months, including 6-month dose escalation data.
    • 09 May 2023 According to a Caribou Biosciences media release, company announced FDA has granted CB-010 Orphan Drug designations.

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