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A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Patients With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma

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Trial Profile

A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Patients With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 17 May 2025

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At a glance

  • Drugs Atezolizumab (Primary) ; Tiragolumab (Primary) ; Cisplatin; Paclitaxel
  • Indications Oesophageal cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms SKYSCRAPER-08
  • Sponsors Roche

Most Recent Events

  • 12 Feb 2025 Planned End Date changed from 14 Aug 2025 to 31 Jan 2026.
  • 20 Jan 2024 Primary endpoint (Independent Review Facility (IRF)-Assessed Progression-Free Survival (PFS)) has been met, according to Results presented at the 2024 Gastrointestinal Cancers Symposium.
  • 20 Jan 2024 Primary endpoint (Overall Survival (OS)) has been met, according to Results presented at the 2024 Gastrointestinal Cancers Symposium.

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