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A Phase 2 Study With Combination Chemotherapy (Gemcitabine and Nab-Paclitaxel), Chemokine (C-X-C) Motif Receptor 4 Inhibitor (BL-8040), and Immune Checkpoint Blockade (Cemiplimab) in METastatic Treatment naïve PANCreas Adenocarcinoma

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Trial Profile

A Phase 2 Study With Combination Chemotherapy (Gemcitabine and Nab-Paclitaxel), Chemokine (C-X-C) Motif Receptor 4 Inhibitor (BL-8040), and Immune Checkpoint Blockade (Cemiplimab) in METastatic Treatment naïve PANCreas Adenocarcinoma

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 01 Dec 2024

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At a glance

  • Drugs Cemiplimab (Primary) ; Gemcitabine (Primary) ; Motixafortide (Primary) ; Paclitaxel (Primary)
  • Indications Adenocarcinoma; Pancreatic cancer
  • Focus First in man; Therapeutic Use
  • Acronyms Chemo4MetPanc

    • Most Recent Events

    • 25 Nov 2024 According to a BioLineRx media release, , patient enrollment has begun at Brown University, and three additional sites are anticipated to begin enrollment over the next two quarters. Full enrollment is anticipated in 2027.
    • 04 Jun 2024 Trial design evaluating the preliminary safety and efficacy ofMotixafortide (CXCR4i), Cemiplimab (aPD1), Gemcitabine, and Nab-paclitaxel (MCGN) in 11 patients with treatment-naive mPDAC were presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 24 May 2024 According to a BioLineRx media release, Updated results from this trial was accepted for poster presentation at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, May 31-June 4, 2024 in Chicago, Illinois.

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