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A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab With or Without Tiragolumab (Anti-TIGIT Antibody) in Patients With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

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Trial Profile

A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab With or Without Tiragolumab (Anti-TIGIT Antibody) in Patients With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 02 Sep 2026

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At a glance

  • Drugs Atezolizumab (Primary) ; Tiragolumab (Primary)
  • Indications Oesophageal cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms SKYSCRAPER-07
  • Sponsors Roche

Most Recent Events

  • 12 Jun 2026 According to Chugai Pharmaceutical Co., Ltd media release, the company announced that it has filed a regulatory application with the Ministry of Health, Labour and Welfare for the Tecentriq or an additional indication as maintenance therapy following definitive chemoradiotherapy in locally advanced esophageal cancer. The filing is based on the results from this trial.
  • 12 Jun 2026 The study has been Completed in Greece
  • 18 Oct 2023 This trial has been completed in Hungary, according to European Clinical trials database record.

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