Trial Profile

A Phase IIIB Multicenter, Randomized, Double-blind, Controlled Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 03 Aug 2026

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At a glance

Drugs Ocrelizumab (Primary) ; Diphenhydramine; Diphenhydramine; Methylprednisolone; Paracetamol
Indications Multiple sclerosis
Focus Registrational; Therapeutic Use
Acronyms GAVOTTE
Sponsors Roche

02 Jul 2026 This trial has been completed in Hungary, Portugal, Denmark, Spain, France, Belgium and Greece, according to Clinical Trials Information System record.
31 May 2025 Planned primary completion date changed from 7 Apr 2025 to 28 Jul 2025.
11 Mar 2024 Planned End Date changed from 26 Jul 2029 to 8 Mar 2029.

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