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A Phase 1 Trial of D2C7-IT in Combination With an Fc-engineered Anti-CD40 Monoclonal Antibody (2141-V11) Administered Intratumorally Via Convection-Enhanced Delivery Followed by Perilymphatic Injections of 2141-V11 and Assessment of the Tumor Monorail for Adult Patients With Recurrent Malignant Glioma

Trial Profile

A Phase 1 Trial of D2C7-IT in Combination With an Fc-engineered Anti-CD40 Monoclonal Antibody (2141-V11) Administered Intratumorally Via Convection-Enhanced Delivery Followed by Perilymphatic Injections of 2141-V11 and Assessment of the Tumor Monorail for Adult Patients With Recurrent Malignant Glioma

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 12 May 2025

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At a glance

  • Drugs 2141-V11 (Primary) ; D2C7-IT (Primary)
  • Indications Glioblastoma; Glioma
  • Focus Adverse reactions; First in man

Most Recent Events

  • 03 Mar 2025 Planned End Date changed from 1 Dec 2025 to 1 Jun 2027.
  • 03 Mar 2025 Planned primary completion date changed from 1 Dec 2024 to 1 Jun 2026.
  • 25 Jan 2024 Planned primary completion date changed from 1 Dec 2023 to 1 Dec 2024.

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