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A Phase I/II Study of Venetoclax in Combination With Azacitidine in Relapsed/Refractory High-Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)

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Trial Profile

A Phase I/II Study of Venetoclax in Combination With Azacitidine in Relapsed/Refractory High-Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 14 Feb 2025

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At a glance

  • Drugs Azacitidine (Primary) ; Azacitidine (Primary) ; Venetoclax (Primary)
  • Indications Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 18 Nov 2024 Status changed from recruiting to active, no longer recruiting.
    • 12 Dec 2023 Results of pooled analysis from NCT04160052, NCT04550442,NCT04655755 ,explaining resistance of GMP pattern and MDS to venetoclax therapy presented at the 65th American Society of Hematology Annual Meeting and Exposition.
    • 15 Jun 2023 Results of pooled analysis from NCT04160052, NCT04550442,NCT04655755 assessing patient and disease characteristics associated with overall response rate (ORR), event-free survival (EFS),and overall survival (OS) in prospective studies of HMA + VEN in HR-MDS presented at the 28th Congress of the European Haematology Association

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