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A Phase 1b Multicentre, Open-label, Modular, Dose-finding and Dose-expansion Study to Explore the Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of Trastuzumab Deruxtecan (T-DXd) in Combination With Other Anti-cancer Agents in Patients With Metastatic HER2-low Breast Cancer (DESTINY-Breast08)

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Trial Profile

A Phase 1b Multicentre, Open-label, Modular, Dose-finding and Dose-expansion Study to Explore the Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of Trastuzumab Deruxtecan (T-DXd) in Combination With Other Anti-cancer Agents in Patients With Metastatic HER2-low Breast Cancer (DESTINY-Breast08)

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 26 Aug 2024

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At a glance

  • Drugs Anastrozole (Primary) ; Capecitabine (Primary) ; Capivasertib (Primary) ; Durvalumab (Primary) ; Fulvestrant (Primary) ; Paclitaxel (Primary) ; Trastuzumab-deruxtecan (Primary)
  • Indications Advanced breast cancer; Male breast cancer
  • Focus Adverse reactions
  • Acronyms DB-08; DESTINY-Breast08
  • Sponsors AstraZeneca

    • Most Recent Events

    • 01 Dec 2023 According to Daiichi Sankyo Company Media Release, results from this study will be presented at the San Antonio Breast Cancer Symposium, 2023.
    • 20 Jun 2023 Planned End Date changed from 10 Aug 2023 to 28 Nov 2025.
    • 20 Jun 2023 Planned primary completion date changed from 10 Aug 2023 to 16 Aug 2023.

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