Trial Profile

Phase I Trial of DNA-PK Inhibitor (M3814) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated Glioblastoma

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 01 Nov 2025

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At a glance

Drugs Peposertib (Primary) ; Temozolomide
Indications Glioblastoma; Glioma; Gliosarcoma
Focus Adverse reactions; Biomarker; Pharmacokinetics

Most Recent Events

28 Oct 2025 Planned End Date changed from 30 Oct 2025 to 31 Dec 2027.
28 Oct 2025 Planned primary completion date changed from 30 Oct 2025 to 31 Dec 2027.
04 Jun 2024 Results(n=18) presented at the 60th Annual Meeting of the American Society of Clinical Oncology

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