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A Randomised, Double-blind, Placebo Controlled, First-in-human Study to Investigate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Response of SLN360 in Subjects With Elevated Lipoprotein(a)

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Trial Profile

A Randomised, Double-blind, Placebo Controlled, First-in-human Study to Investigate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Response of SLN360 in Subjects With Elevated Lipoprotein(a)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 10 Apr 2024

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At a glance

  • Drugs Zerlasiran (Primary)
  • Indications Cardiovascular disorders; Dyslipidaemias; Hyperlipidaemia
  • Focus Adverse reactions; First in man
  • Acronyms APOLLO
  • Sponsors Silence Therapeutics
  • Most Recent Events

    • 08 Apr 2024 According to a Silence Therapeutics media release, results from the single ascending dose portion of the trial in healthy participants were previously published in the April 2022 issue of JAMA.
    • 08 Apr 2024 According to a silence therapeutics media release, additional results from the APOLLO phase 1 study of zerlasiran (SLN360) in subjects with baseline lipoprotein(a), or Lp(a), levels at or over 150 nmol/L were published in the Journal of the American Medical Association (JAMA).
    • 01 Nov 2023 According to silence therapeutics media release, the company plans to present further results from the APOLLO multiple dose study at a future cardiovascular medicines conference.
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