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Study on the effects of an OCT2/MATE1 substrate (metformin) and inhibitor (cimetidine) on the exposure of trifluridine/tipiracil (Lonsurf) in patients with metastatic colorectal cancer (mCRC)

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Trial Profile

Study on the effects of an OCT2/MATE1 substrate (metformin) and inhibitor (cimetidine) on the exposure of trifluridine/tipiracil (Lonsurf) in patients with metastatic colorectal cancer (mCRC)

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 30 May 2023

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At a glance

  • Drugs Tipiracil/trifluridine (Primary) ; Cimetidine; Metformin
  • Indications Carcinoma; Colorectal cancer
  • Focus Pharmacokinetics
  • Acronyms SUMO trial
  • Sponsors Servier

    • Most Recent Events

    • 29 May 2023 Status changed from recruiting to completed.
    • 01 Aug 2021 Planned End Date changed from 5 Jun 2022 to 31 Dec 2021.
    • 22 Sep 2020 New trial record

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