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A Phase 1, Randomized, Placebo-Controlled, Double-Blind Study to Determine the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Of DNL151 in Healthy Volunteers

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Trial Profile

A Phase 1, Randomized, Placebo-Controlled, Double-Blind Study to Determine the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Of DNL151 in Healthy Volunteers

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 28 Feb 2023

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At a glance

  • Drugs DNL-151 (Primary)
  • Indications Parkinson's disease
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors Denali Therapeutics Inc

    • Most Recent Events

    • 18 Feb 2023 Results of pooled analysis from (DNLI-C-0001, DNLI-C-0003) assessing to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the potent, selective, CNS-penetrant LRRK2 inhibitor BIIB122 (DNL151) in healthy participants and patients with PD published in the Movement Disorders
    • 22 Sep 2021 Results assessing safety, tolerability, pharmacokinetics and pharmacodynamics of DNL151 from two phase 1 clinical studies: DNLI-C0001 and DNLI-C0003 presented at the 25th International Congress of Parkinson's Disease and Movement Disorders
    • 03 May 2021 According to a Denali Therapeutics media release, results from this study were presented at the International Association of Parkinsonism and Related Disorders Virtual Congress 2021.

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