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A Multi-center, Randomised, Open Label Study of Nitazoxanide (NTZ), or Sofosbuvir and Daclatasvir (SOF/DCV), Compared to no Pharmacological Intervention for the Prevention of COVID-19 Disease in Healthcare Workers and Inner City Inhabitants at High Risk of Exposure to SARS-CoV-2

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Trial Profile

A Multi-center, Randomised, Open Label Study of Nitazoxanide (NTZ), or Sofosbuvir and Daclatasvir (SOF/DCV), Compared to no Pharmacological Intervention for the Prevention of COVID-19 Disease in Healthcare Workers and Inner City Inhabitants at High Risk of Exposure to SARS-CoV-2

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 29 Aug 2022

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At a glance

  • Drugs Daclatasvir/sofosbuvir (Primary) ; Nitazoxanide (Primary)
  • Indications COVID 2019 infections
  • Focus Therapeutic Use
  • Acronyms COVER; COVER HCW

    • Most Recent Events

    • 12 Aug 2022 Results (n=261) of primary efficacy analysis and safety analysis from Arm A, B and C published in the Journal of Antimicrobial Chemotherapy
    • 12 Aug 2022 Primary endpoint has not been met. (Number of SARS-CoV-2 infections) , according to Results published in the Journal of Antimicrobial Chemotherapy
    • 02 Aug 2022 Results presented at the 24th International AIDS Conference

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