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A Phase 2b, Randomized, Active-Controlled, Double-Blind, Dose-Ranging Clinical Study to Evaluate a Switch to Islatravir (ISL) and MK-8507 Once-Weekly in Adults With HIV-1 Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Once-Daily

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A Phase 2b, Randomized, Active-Controlled, Double-Blind, Dose-Ranging Clinical Study to Evaluate a Switch to Islatravir (ISL) and MK-8507 Once-Weekly in Adults With HIV-1 Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Once-Daily

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 13 Jan 2025

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At a glance

  • Drugs Islatravir (Primary) ; Ulonivirine (Primary) ; Bictegravir/emtricitabine/tenofovir alafenamide
  • Indications HIV-1 infections
  • Focus Adverse reactions
  • Acronyms IMAGINE-DR; MK-8591-013
  • Sponsors Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 09 Jan 2025 Planned End Date changed from 31 Mar 2025 to 31 Jan 2025.
    • 09 Jan 2025 Planned primary completion date changed from 31 Mar 2025 to 31 Jan 2025.
    • 19 Nov 2024 Planned End Date changed from 18 Dec 2024 to 31 Mar 2025.

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