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A Phase 2b, Randomized, Active-Controlled, Double-Blind, Dose-Ranging Clinical Study to Evaluate a Switch to Islatravir (ISL) and MK-8507 Once-Weekly in Adults With HIV-1 Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Once-Daily

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Trial Profile

A Phase 2b, Randomized, Active-Controlled, Double-Blind, Dose-Ranging Clinical Study to Evaluate a Switch to Islatravir (ISL) and MK-8507 Once-Weekly in Adults With HIV-1 Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Once-Daily

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 22 Apr 2024

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At a glance

  • Drugs Islatravir (Primary) ; Ulonivirine (Primary) ; Bictegravir/emtricitabine/tenofovir alafenamide
  • Indications HIV-1 infections
  • Focus Adverse reactions
  • Acronyms IMAGINE-DR; MK-8591-013
  • Sponsors Merck Sharp & Dohme Corp.
  • Most Recent Events

    • 12 Dec 2023 Planned End Date changed from 26 Dec 2023 to 30 Sep 2024.
    • 12 Dec 2023 Planned primary completion date changed from 26 Dec 2023 to 30 Sep 2024.
    • 12 Dec 2023 Status changed from suspended to active, no longer recruiting.
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