Trial Profile

A Phase 2 Basket Study of Tucatinib in Combination With Trastuzumab in Subjects With Previously Treated, Locally Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 28 Aug 2026

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At a glance

Drugs Trastuzumab (Primary) ; Tucatinib (Primary) ; Fulvestrant
Indications Advanced breast cancer; Biliary cancer; Brain cancer; Cervical cancer; HER2 negative breast cancer; Male breast cancer; Non-small cell lung cancer; Solid tumours; Urogenital cancer; Uterine cancer
Focus Therapeutic Use
Sponsors Seagen

Most Recent Events

21 Aug 2026 Planned End Date changed from 30 Apr 2026 to 31 Dec 2026.
19 Jun 2025 Planned End Date changed from 30 Apr 2025 to 30 Apr 2026.
30 Apr 2025 Planned End Date changed from 31 May 2025 to 30 Apr 2025.

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