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A Phase 2 Basket Study of Tucatinib in Combination With Trastuzumab in Subjects With Previously Treated, Locally Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

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Trial Profile

A Phase 2 Basket Study of Tucatinib in Combination With Trastuzumab in Subjects With Previously Treated, Locally Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 05 Jul 2024

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At a glance

  • Drugs Trastuzumab (Primary) ; Tucatinib (Primary) ; Fulvestrant
  • Indications Advanced breast cancer; Biliary cancer; Brain cancer; Cervical cancer; Non-small cell lung cancer; Solid tumours; Urogenital cancer; Uterine cancer
  • Focus Therapeutic Use
  • Sponsors Seagen

    • Most Recent Events

    • 04 Jun 2024 Results ( As of Nov 1, 2023, n=31) assessing efficacy and safety results of TUC combined with Tras in pts with previously treated HER2-mut MBC presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 29 Apr 2024 According to Pfizer media release, data from this trial will be presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
    • 25 Oct 2023 This trial has been completed in Poland, according to European Clinical Trials Database record.

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