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An Open, Multicenter, Phase Ib/II Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection in Patients With Advanced Gastric/ Gastroesophageal Junction Adenocarcinoma and Pancreatic Cancer

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Trial Profile

An Open, Multicenter, Phase Ib/II Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection in Patients With Advanced Gastric/ Gastroesophageal Junction Adenocarcinoma and Pancreatic Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 11 Jun 2025

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At a glance

  • Drugs Satricabtagene autoleucel (Primary) ; Docetaxel; Irinotecan; Nivolumab; Paclitaxel; Rivoceranib
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer; Pancreatic cancer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors CARsgen

Most Recent Events

  • 01 Jun 2025 According to a CARsgen media release, company announces that the results of the pivotal Phase II clinical trial in China have been published in The Lancet and were orally presented at the 2025 ASCO Annual Meeting.
  • 28 May 2025 According to a CARsgen media release, company announces that the Center for Drug Evaluation (CDE) of China's National Medical Products Administration (NMPA) has granted Priority Review to satricabtagene autoleucel ("satri-cel", CT041)(an autologous CAR T-cell product candidate against protein Claudin18.2), for the treatment of Claudin18.2-positive advanced gastric/gastroesophageal junction adenocarcinoma (G/GEJA) in patients who have failed at least two prior lines of therapy.
  • 22 May 2025 According to a CARsgen media release, an abstract of the research results of this confirmatory Phase II clinical trial is available on the American Society of Clinical Oncology (ASCO) website, and will be presented in an oral session on May 31, 2025, 3:00-6:00 PM CDT.

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