Trial Profile

An Open-Label, Randomized, Phase 2, Umbrella Study to Investigate the Biological Rational of Various Neoadjuvant Therapies for Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder Who Are Cisplatin-Ineligible or Refuse Cisplatin Therapy and Undergoing Radical Cystectomy

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 12 Mar 2025

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At a glance

Drugs Epacadostat (Primary) ; Pemigatinib (Primary) ; Retifanlimab (Primary)
Indications Bladder cancer; Carcinoma
Focus Therapeutic Use
Acronyms OPTIMUS
Sponsors Incyte Corporation

09 Feb 2024 Status changed from active, no longer recruiting to discontinued. (Business Decision. No safety concerns contributed to this decision.)
10 Nov 2023 Status changed from recruiting to active, no longer recruiting.
15 Nov 2022 Planned number of patients changed from 81 to 45.

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