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A prospective, three period,Sequential , crossover study of drug-drug Interactions for Tolvaptan at BCRP and the Oxobutyric Acid Metabolite at OATP1B1 and OAT3 Transporters in Healthy Adult Subjects

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Trial Profile

A prospective, three period,Sequential , crossover study of drug-drug Interactions for Tolvaptan at BCRP and the Oxobutyric Acid Metabolite at OATP1B1 and OAT3 Transporters in Healthy Adult Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 22 Oct 2020

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At a glance

  • Drugs Furosemide (Primary) ; Tolvaptan (Primary)
  • Indications Ascites; Autosomal dominant polycystic kidney disease; Benign prostatic hyperplasia; Cardiac oedema; Heart failure; Hyponatraemia; Oedema; Renal failure
  • Focus Pharmacokinetics

    • Most Recent Events

    • 22 Oct 2020 New trial record
    • 23 Sep 2020 Results presented at the 2020 American College of Clinical Pharmacology Annual Meeting

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