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An Open-Label, Phase 1/2 Study of ORIC-114 As a Single Agent or in Combination with Chemotherapy, in Patients with Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

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Trial Profile

An Open-Label, Phase 1/2 Study of ORIC-114 As a Single Agent or in Combination with Chemotherapy, in Patients with Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 25 Feb 2025

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At a glance

  • Drugs Carboplatin (Primary) ; ORIC 114 (Primary) ; Pemetrexed (Primary)
  • Indications Advanced breast cancer; Brain metastases; CNS cancer; HER2 positive breast cancer; Male breast cancer; Non-small cell lung cancer; Solid tumours
  • Focus First in man; Pharmacokinetics; Registrational
  • Sponsors ORIC Pharmaceuticals

Most Recent Events

  • 18 Feb 2025 According to an ORIC Pharmaceuticals media release, 2L EGFR exon 20 and 2L+ HER2 exon 20 data expected in 1H 2025, 2L+ EGFR atypical data expected in 2H 2025,: 1L EGFR exon 20 data expected in 1H 2026
  • 13 Jan 2025 According to an ORIC Pharmaceuticals media release, the company announced the completion of the dose escalation portion of the Phase 1b trial of ORIC-114 and the selection of two provisional recommended phase 2 doses.
  • 23 Oct 2024 According to an ORIC Pharmaceuticals media release, the company will discuss this study at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics

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