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A Phase II, Multicenter, Open-Label, Single Arm Study to Evaluate the Pharmacodynamic Effects of Once Weekly Administration of Gantenerumab in Participants With Early (Prodromal to Mild) Alzheimer's Disease

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Trial Profile

A Phase II, Multicenter, Open-Label, Single Arm Study to Evaluate the Pharmacodynamic Effects of Once Weekly Administration of Gantenerumab in Participants With Early (Prodromal to Mild) Alzheimer's Disease

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 29 Mar 2024

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At a glance

  • Drugs Gantenerumab (Primary)
  • Indications Alzheimer's disease
  • Focus Pharmacodynamics
  • Acronyms GRADUATION
  • Sponsors Roche

    • Most Recent Events

    • 02 Feb 2024 This study has been completed in France, according to European Clinical Trials Database record.
    • 27 Apr 2023 Results from NCT02882009 and NCT04592341 assessing value and feasibility of subcutaneous administration of Gantenerumab , presented at the 75th Annual Meeting of the American Academy of Neurology 2023
    • 28 Mar 2023 Status changed from active, no longer recruiting to discontinued (Decision to terminate development of Gantenerumab for treatment of prodromal/mild/early-stageAlzheimer's disease following results of a pre-planned analysis of the safety and efficacy ofGant in Graduate I&II (WN29922/WN39658))

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