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A Randomized, Double-blind, Placebo-controlled, Phase III Study of Neoadjuvant-Adjuvant Durvalumab and FLOT Chemotherapy Followed by Adjuvant Durvalumab in Patients With Resectable Gastric and Gastroesophageal Junction Cancer (GC/GEJC)

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Trial Profile

A Randomized, Double-blind, Placebo-controlled, Phase III Study of Neoadjuvant-Adjuvant Durvalumab and FLOT Chemotherapy Followed by Adjuvant Durvalumab in Patients With Resectable Gastric and Gastroesophageal Junction Cancer (GC/GEJC)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 16 Sep 2026

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At a glance

  • Drugs Durvalumab (Primary) ; Docetaxel; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms MATTERHORN
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 16 Mar 2026 According to an AstraZeneca media release, regulatory applications are currently under review in Japan and several other countries for this indication.
  • 16 Mar 2026 According to an AstraZeneca media release, Imfinzi (durvalumab) in combination with standard of care chemotherapy (fluorouracil, leucovorin, oxaliplatin, and docetaxel) has been approved in the European Union (EU) for the treatment of adult patients with resectable, early-stage and locally advanced (Stages II, III, IVA) gastric and gastroesophageal junction (GEJ) cancers.The approval by the European Commission follows the positive opinion of the Committee for Medicinal Products for Human Use.
  • 02 Feb 2026 According to an AstraZeneca media release, The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency based its positive opinion on event-free survival (EFS) and overall survival (OS) data from the MATTERHORN Phase III trial.

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